6G7A
Crystal structure of human carbonic anhydrase isozyme XII 2-(benzylamino)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Summary for 6G7A
Entry DOI | 10.2210/pdb6g7a/pdb |
Related | 6G5L 6G5U 6G6T |
Descriptor | Carbonic anhydrase 12, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 122211.12 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2018-04-05, release date: 2019-03-13, Last modification date: 2024-01-17) |
Primary citation | Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Kisonaite, M.,Smirnov, A.,Manakova, E.,Grazulis, S.,Matulis, D. Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem, 156:61-78, 2018 Cited by PubMed: 30006175DOI: 10.1016/j.ejmech.2018.06.059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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