6G2Q

Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL (S-isomer), beta, gamma dTTP analogue

Summary for 6G2Q

• Entry DOI: 10.2210/pdb6g2q/pdb
• Descriptor: Template Strand, Primer Strand, Downstream Primer Strand, ... (9 entities in total)
• Functional Keywords: dna polymerase beta, conformational change, enzyme mechanism, lfer, replication
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48319.24

Authors

Batra, V.K.,Wilson, S.H. (deposition date: 2018-03-23, release date: 2018-07-04, Last modification date: 2024-01-17)

• Primary citation: Batra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.; Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.; Biochemistry, 57:3934-3944, 2018; PubMed: 29874056; DOI: 10.1021/acs.biochem.8b00418

Experimental method

X-RAY DIFFRACTION (2.148 Å)