6G2C
X-ray structure of NSD3-PWWP1 in complex with compound 9
Summary for 6G2C
Entry DOI | 10.2210/pdb6g2c/pdb |
Related | 6G24 6G25 6G27 6G29 6G2B |
Descriptor | Histone-lysine N-methyltransferase NSD3, 3,5-dimethyl-4-(1-methyl-5-pyridin-4-yl-imidazol-4-yl)-1,2-oxazole (3 entities in total) |
Functional Keywords | inhibitor, pwwp domain, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16525.69 |
Authors | Boettcher, J.,Muellauer, B.J.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2018-03-22, release date: 2019-06-26, Last modification date: 2024-05-08) |
Primary citation | Bottcher, J.,Dilworth, D.,Reiser, U.,Neumuller, R.A.,Schleicher, M.,Petronczki, M.,Zeeb, M.,Mischerikow, N.,Allali-Hassani, A.,Szewczyk, M.M.,Li, F.,Kennedy, S.,Vedadi, M.,Barsyte-Lovejoy, D.,Brown, P.J.,Huber, K.V.M.,Rogers, C.M.,Wells, C.I.,Fedorov, O.,Rumpel, K.,Zoephel, A.,Mayer, M.,Wunberg, T.,Bose, D.,Zahn, S.,Arnhof, H.,Berger, H.,Reiser, C.,Hormann, A.,Krammer, T.,Corcokovic, M.,Sharps, B.,Winkler, S.,Haring, D.,Cockcroft, X.L.,Fuchs, J.E.,Mullauer, B.,Weiss-Puxbaum, A.,Gerstberger, T.,Boehmelt, G.,Vakoc, C.R.,Arrowsmith, C.H.,Pearson, M.,McConnell, D.B. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol., 15:822-829, 2019 Cited by PubMed: 31285596DOI: 10.1038/s41589-019-0310-x PDB entries with the same primary citation |
Experimental method |
Structure validation
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