6FO5
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR #17
Summary for 6FO5
Entry DOI | 10.2210/pdb6fo5/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-[[4-[[7-ethyl-2,6-bis(oxidanylidene)purin-3-yl]methyl]phenyl]methyl]-2-oxidanylidene-1,3,4,5-tetrahydro-1-benzazepine-7-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4(bd1), dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15684.02 |
Authors | |
Primary citation | Hoffer, L.,Voitovich, Y.V.,Raux, B.,Carrasco, K.,Muller, C.,Fedorov, A.Y.,Derviaux, C.,Amouric, A.,Betzi, S.,Horvath, D.,Varnek, A.,Collette, Y.,Combes, S.,Roche, P.,Morelli, X. Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach. J. Med. Chem., 61:5719-5732, 2018 Cited by PubMed: 29883107DOI: 10.1021/acs.jmedchem.8b00653 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.95 Å) |
Structure validation
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