6FMO
Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi
Summary for 6FMO
| Entry DOI | 10.2210/pdb6fmo/pdb |
| Descriptor | Sterol 14alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, Obtusifoliol, ... (4 entities in total) |
| Functional Keywords | sterol biosynthesis, cyp51, oxidoreductase, monooxygenase, substrate binding, protein binding |
| Biological source | Trypanosoma cruzi |
| Total number of polymer chains | 4 |
| Total formula weight | 225050.85 |
| Authors | Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2018-02-01, release date: 2018-10-24, Last modification date: 2024-01-17) |
| Primary citation | Hargrove, T.Y.,Wawrzak, Z.,Fisher, P.M.,Child, S.A.,Nes, W.D.,Guengerich, F.P.,Waterman, M.R.,Lepesheva, G.I. Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51. J. Biol. Chem., 293:19344-19353, 2018 Cited by PubMed: 30327430DOI: 10.1074/jbc.RA118.005850 PDB entries with the same primary citation |
| Experimental method |
Structure validation
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