6FMO
Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Sterol 14alpha-demethylase | polymer | 485 | 55326.2 | 4 | UniProt (M1FYE4) Pfam (PF00067) UniProt (by SIFTS) (Q7Z1V1) In PDB | Trypanosoma cruzi | |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, C | Obtusifoliol | non-polymer | 426.7 | 3 | Chemie (DVE) | |||
4 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 481 (UniProt: M1FYE4)
PDB | External Database | Details |
---|---|---|
Leu 31 | Asp 31 | conflict |
Phe 105 | Ile 105 | engineered mutation |
Pro 355 | Ser 355 | conflict |
His 482 | - | expression tag |
His 483 | - | expression tag |
His 484 | - | expression tag |
His 485 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 221304.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3746.1 | |
All* | Total formula weight | 225050.9 |