6FGB
Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab
Summary for 6FGB
Entry DOI | 10.2210/pdb6fgb/pdb |
Descriptor | IgG receptor FcRn large subunit p51, Beta-2-microglobulin, 1519.g57- Light chain, ... (7 entities in total) |
Functional Keywords | fcrn, rozanolixizumab, ecd, fab, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 97353.17 |
Authors | Sarkar, K.,Ceska, T.,Meier, C. (deposition date: 2018-01-10, release date: 2018-08-29, Last modification date: 2024-01-17) |
Primary citation | Smith, B.,Kiessling, A.,Lledo-Garcia, R.,Dixon, K.L.,Christodoulou, L.,Catley, M.C.,Atherfold, P.,D'Hooghe, L.E.,Finney, H.,Greenslade, K.,Hailu, H.,Kevorkian, L.,Lightwood, D.,Meier, C.,Munro, R.,Qureshi, O.,Sarkar, K.,Shaw, S.P.,Tewari, R.,Turner, A.,Tyson, K.,West, S.,Shaw, S.,Brennan, F.R. Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration. MAbs, 10:1111-1130, 2018 Cited by PubMed: 30130439DOI: 10.1080/19420862.2018.1505464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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