6EPN
Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2
Summary for 6EPN
Entry DOI | 10.2210/pdb6epn/pdb |
Related | 6EPL 6EPM 6EPO 6EPP |
Descriptor | GTPase KRas, Son of sevenless homolog 1, GLYCEROL, ... (6 entities in total) |
Functional Keywords | guanine nucleotide exchange factor, gef, fragment screen, gtpase, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 76851.59 |
Authors | Hillig, R.C.,Moosmayer, D.,Hilpmann, A.,Bader, B.,Schroeder, J.,Wortmann, L.,Sautier, B.,Kahmann, J.,Wegener, D.,Briem, H.,Petersen, K.,Badock, V. (deposition date: 2017-10-12, release date: 2019-02-06, Last modification date: 2024-01-17) |
Primary citation | Hillig, R.C.,Sautier, B.,Schroeder, J.,Moosmayer, D.,Hilpmann, A.,Stegmann, C.M.,Werbeck, N.D.,Briem, H.,Boemer, U.,Weiske, J.,Badock, V.,Mastouri, J.,Petersen, K.,Siemeister, G.,Kahmann, J.D.,Wegener, D.,Bohnke, N.,Eis, K.,Graham, K.,Wortmann, L.,von Nussbaum, F.,Bader, B. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116:2551-2560, 2019 Cited by PubMed: 30683722DOI: 10.1073/pnas.1812963116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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