6EPN
Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | GTPase KRas | polymer | 170 | 19386.8 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (S) | Son of sevenless homolog 1 | polymer | 487 | 57103.3 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) | Homo sapiens (Human) | SOS-1 |
| 3 | C (R) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (S) | 1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-ethanone | non-polymer | 191.2 | 1 | Chemie (BQ2) | |||
| 5 | E (S) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | F, G (R, S) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
R: 1 - 169 (UniProt: P01116)
S: 563 - 1049 (UniProt: Q07889)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Glu 126 | Asp 126 | engineered mutation |
| Ser 127 | Thr 127 | engineered mutation |
| Arg 128 | Lys 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 563 | Lys 563 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76490.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 361.5 | |
| All* | Total formula weight | 76851.6 |
