6EOY
Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline
Summary for 6EOY
Entry DOI | 10.2210/pdb6eoy/pdb |
Descriptor | Transthyretin, 4-(1,3-benzothiazol-2-yl)-2-methyl-aniline (3 entities in total) |
Functional Keywords | transthyretin, amyloid, ttr amyloid inhibitor, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 25692.85 |
Authors | Leite, J.P.,Gales, L. (deposition date: 2017-10-10, release date: 2021-10-06, Last modification date: 2024-01-17) |
Primary citation | Cotrina, E.Y.,Santos, L.M.,Rivas, J.,Blasi, D.,Leite, J.P.,Liz, M.A.,Busquets, M.A.,Planas, A.,Prohens, R.,Gimeno, A.,Jimenez-Barbero, J.,Gales, L.,Llop, J.,Quintana, J.,Cardoso, I.,Arsequell, G. Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. Eur.J.Med.Chem., 226:113847-113847, 2021 Cited by PubMed: 34555615DOI: 10.1016/j.ejmech.2021.113847 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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