6EK3

PARP15 CATALYTIC DOMAIN MUTANT (Y598L) IN COMPLEX WITH OUL35

Summary for 6EK3

• Entry DOI: 10.2210/pdb6ek3/pdb
• Descriptor: Poly [ADP-ribose] polymerase 15, 4-(4-aminocarbonylphenoxy)benzamide (3 entities in total)
• Functional Keywords: inhibitor, oul35, signaling protein, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 51291.40

Authors

Maksimainen, M.M.,Lehtio, L. (deposition date: 2017-09-25, release date: 2018-07-25, Last modification date: 2024-01-17)

• Primary citation: Murthy, S.,Desantis, J.,Verheugd, P.,Maksimainen, M.M.,Venkannagari, H.,Massari, S.,Ashok, Y.,Obaji, E.,Nkizinkinko, Y.,Luscher, B.,Tabarrini, O.,Lehtio, L.; 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10.; Eur J Med Chem, 156:93-102, 2018; PubMed: 30006177; DOI: 10.1016/j.ejmech.2018.06.047

Experimental method

X-RAY DIFFRACTION (1.6 Å)