6EK3

PARP15 CATALYTIC DOMAIN MUTANT (Y598L) IN COMPLEX WITH OUL35

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Poly [ADP-ribose] polymerase 15	polymer	221	25389.4	2	UniProt (Q460N3) Pfam (PF00644) In PDB	Homo sapiens (Human)	PARP-15,ADP-ribosyltransferase diphtheria toxin-like 7,ARTD7,B-aggressive lymphoma protein 3
2	A, B	4-(4-aminocarbonylphenoxy)benzamide	non-polymer		256.3	2	Chemie (OUL)
3		water	water		18.0	321	Chemie (HOH)

Sequence modifications

A, B: 286 - 483 (UniProt: Q460N3)

PDB	External Database	Details
Met 263	-	initiating methionine
His 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
Ser 270	-	expression tag
Ser 271	-	expression tag
Gly 272	-	expression tag
Val 273	-	expression tag
Asp 274	-	expression tag
Leu 275	-	expression tag
Gly 276	-	expression tag
Thr 277	-	expression tag
Glu 278	-	expression tag
Asn 279	-	expression tag
Leu 280	-	expression tag
Tyr 281	-	expression tag
Phe 282	-	expression tag
Gln 283	-	expression tag
Ser 284	-	expression tag
Met 285	-	expression tag
Leu 403	Tyr 598	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50778.9
Non-Polymers*	Number of molecules	2
	Total formula weight	512.5
All*	Total formula weight	51291.4

*Water molecules are not included.