6E3Z
Structure of Bace-1 in complex with Ligand 8
Summary for 6E3Z
Entry DOI | 10.2210/pdb6e3z/pdb |
Descriptor | Beta-secretase 1, N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-3,5-dichloropyridine-2-carboxamide (3 entities in total) |
Functional Keywords | bace protease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 146194.30 |
Authors | Shaffer, P.L. (deposition date: 2018-07-16, release date: 2019-09-11, Last modification date: 2020-03-25) |
Primary citation | Gijsen, H.J.M.,Lin, J.,Houpis, Y. Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor Acs Symp.Ser., 1307:-, 2020 Cited by DOI: 10.1021/bk-2018-1307.ch004PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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