6DTE
GlcNAc-inspired cyclophellitol bound to NagZ
Summary for 6DTE
Entry DOI | 10.2210/pdb6dte/pdb |
Descriptor | Beta-hexosaminidase, 2,2,2-trifluoro-N-[(1R,2R,3R,4R,5R,6R)-2,3,5,6-tetrahydroxy-4-(hydroxymethyl)cyclohexyl]acetamide (3 entities in total) |
Functional Keywords | antibiotic potentiator, antibiotic adjuvant, nagz, glycosides, epoxide, glcnac, antibiotic resistance, ampc, hydrolase |
Biological source | Burkholderia cenocepacia |
Total number of polymer chains | 2 |
Total formula weight | 76811.94 |
Authors | Mark, B.L.,Winogrodzki, J.L. (deposition date: 2018-06-15, release date: 2019-04-24, Last modification date: 2023-10-11) |
Primary citation | Ho, L.A.,Winogrodzki, J.L.,Debowski, A.W.,Madden, Z.,Vocadlo, D.J.,Mark, B.L.,Stubbs, K.A. A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa. Chem. Commun. (Camb.), 54:10630-10633, 2018 Cited by PubMed: 30178799DOI: 10.1039/c8cc05281f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.929 Å) |
Structure validation
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