6DMO
Cryo-EM structure of human Ptch1 with three mutations L282Q/T500F/P504L
Summary for 6DMO
Entry DOI | 10.2210/pdb6dmo/pdb |
EMDB information | 7964 |
Descriptor | Protein patched homolog 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | receptor, rnd family, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 151797.10 |
Authors | Yan, N.,Gong, X.,Qian, H.W. (deposition date: 2018-06-05, release date: 2018-07-11, Last modification date: 2020-07-29) |
Primary citation | Gong, X.,Qian, H.,Cao, P.,Zhao, X.,Zhou, Q.,Lei, J.,Yan, N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361:-, 2018 Cited by PubMed: 29954986DOI: 10.1126/science.aas8935 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.1 Å) |
Structure validation
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