6CXS
Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine
Summary for 6CXS
Entry DOI | 10.2210/pdb6cxs/pdb |
Related | 4JKM |
Descriptor | Beta-glucuronidase, Maltose/maltodextrin-binding periplasmic protein, 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, ... (4 entities in total) |
Functional Keywords | hydrolase-hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Clostridium perfringens (strain 13 / Type A) More |
Total number of polymer chains | 4 |
Total formula weight | 226983.78 |
Authors | Wallace, B.D.,Redinbo, M.R. (deposition date: 2018-04-04, release date: 2019-04-17, Last modification date: 2023-10-04) |
Primary citation | Bhatt, A.P.,Pellock, S.J.,Biernat, K.A.,Walton, W.G.,Wallace, B.D.,Creekmore, B.C.,Letertre, M.M.,Swann, J.R.,Wilson, I.D.,Roques, J.R.,Darr, D.B.,Bailey, S.T.,Montgomery, S.A.,Roach, J.M.,Azcarate-Peril, M.A.,Sartor, R.B.,Gharaibeh, R.Z.,Bultman, S.J.,Redinbo, M.R. Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy. Proc.Natl.Acad.Sci.USA, 2020 Cited by PubMed: 32170007DOI: 10.1073/pnas.1918095117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report