Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CXS

Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004565	molecular_function	beta-galactosidase activity
A	0004566	molecular_function	beta-glucuronidase activity
A	0005102	molecular_function	signaling receptor binding
A	0005615	cellular_component	extracellular space
A	0005975	biological_process	carbohydrate metabolic process
A	0008152	biological_process	metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019391	biological_process	glucuronoside catabolic process
A	0030246	molecular_function	carbohydrate binding
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004565	molecular_function	beta-galactosidase activity
B	0004566	molecular_function	beta-glucuronidase activity
B	0005102	molecular_function	signaling receptor binding
B	0005615	cellular_component	extracellular space
B	0005975	biological_process	carbohydrate metabolic process
B	0008152	biological_process	metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0019391	biological_process	glucuronoside catabolic process
B	0030246	molecular_function	carbohydrate binding
C	0005515	molecular_function	protein binding
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	0071702	biological_process	organic substance transport
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
D	0005515	molecular_function	protein binding
D	0006974	biological_process	DNA damage response
D	0008643	biological_process	carbohydrate transport
D	0015144	molecular_function	carbohydrate transmembrane transporter activity
D	0015768	biological_process	maltose transport
D	0016020	cellular_component	membrane
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0034219	biological_process	carbohydrate transmembrane transport
D	0034289	biological_process	detection of maltose stimulus
D	0042597	cellular_component	periplasmic space
D	0042956	biological_process	maltodextrin transmembrane transport
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D	0055085	biological_process	transmembrane transport
D	0060326	biological_process	cell chemotaxis
D	0071702	biological_process	organic substance transport
D	1901982	molecular_function	maltose binding
D	1990060	cellular_component	maltose transport complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue FJV A 601

Chain	Residue
A	PHE363
A	MET364
A	PHE368
A	GLU412
A	LEU447
A	TYR472
A	ILE562
A	ARG563

site_id	AC2
Number of Residues	6
Details	binding site for residue FJV B 601

Chain	Residue
B	PHE368
B	GLU412
B	LEU447
B	MET448
B	TYR472
B	MET364

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
C	PRO109-ASN126

site_id	PS00608
Number of Residues	15
Details	GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DKNHPCVVMWSva.NE

Chain	Residue	Details
A	ASP398-GLU412

site_id	PS00719
Number of Residues	26
Details	GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NsFRTSHYPyseeIMrlaDreGIVVI

Chain	Residue	Details
A	ASN326-ILE351

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250\|UniProtKB:P05804

Chain	Residue	Details
A	GLU412
B	GLU412

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250\|UniProtKB:P05804

Chain	Residue	Details
A	GLU505
B	GLU505

site_id	SWS_FT_FI3
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P05804

Chain	Residue	Details
A	ASP164
A	ASN411
A	ASN466
A	TYR472
A	GLU505
A	TRP550
A	LYS569
B	ASP164
B	ASN411
B	ASN466
B	TYR472
B	GLU505
B	TRP550
B	LYS569

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)