6CVY
Crystal structure of HCV NS3/4A WT protease in complex with AJ-21 (MK-5172 linear analogue)
Summary for 6CVY
Entry DOI | 10.2210/pdb6cvy/pdb |
Descriptor | NS3 protease, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepacivirus C |
Total number of polymer chains | 1 |
Total formula weight | 22558.22 |
Authors | Matthew, A.N.,Schiffer, C.A. (deposition date: 2018-03-29, release date: 2018-08-08, Last modification date: 2023-10-04) |
Primary citation | Rusere, L.N.,Matthew, A.N.,Lockbaum, G.J.,Jahangir, M.,Newton, A.,Petropoulos, C.J.,Huang, W.,Kurt Yilmaz, N.,Schiffer, C.A.,Ali, A. Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants. ACS Med Chem Lett, 9:691-696, 2018 Cited by PubMed: 30034602DOI: 10.1021/acsmedchemlett.8b00150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.798 Å) |
Structure validation
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