6CVY

Crystal structure of HCV NS3/4A WT protease in complex with AJ-21 (MK-5172 linear analogue)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

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site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 1202

Chain	Residue
A	HOH1410
A	HOH1426
A	ARG1109
A	HIS1110
A	HOH1317
A	HOH1365
A	HOH1376

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site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 A 1203

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	FHD1205
A	HOH1358
A	HOH1375
A	HOH1379
A	HOH1404
A	HOH1430

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site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 1204

Chain	Residue
A	LYS1080
A	ARG1155
A	PRO1171
A	SER1174
A	HOH1389

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site_id	AC5
Number of Residues	24
Details	binding site for residue FHD A 1205

Chain	Residue
A	HIS982
A	GLN1041
A	PHE1043
A	TYR1056
A	HIS1057
A	VAL1078
A	ASP1081
A	ARG1123
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	VAL1158
A	ASP1168
A	SO41203
A	HOH1340
A	HOH1413
A	HOH1419
A	HOH1445

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site_id	AC6
Number of Residues	4
Details	binding site for residue GOL A 1206

Chain	Residue
A	ASN1049
A	ASP1121
A	SER1122
A	HOH1408

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