6CQF

Crystal structure of HPK1 in complex an inhibitor G1858

Summary for 6CQF

Entry DOI	10.2210/pdb6cqf/pdb
Descriptor	Mitogen-activated protein kinase kinase kinase kinase 1, N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine (3 entities in total)
Functional Keywords	protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33548.89
Authors	Wu, P.,Lehoux, I.,Mortara, K.,Franke, Y.,Chan, B.K.,Wang, W. (deposition date: 2018-03-15, release date: 2018-12-19, Last modification date: 2024-03-13)
Primary citation	Wu, P.,Sneeringer, C.J.,Pitts, K.E.,Day, E.S.,Chan, B.K.,Wei, B.,Lehoux, I.,Mortara, K.,Li, H.,Wu, J.,Franke, Y.,Moffat, J.G.,Grogan, J.L.,Heffron, T.P.,Wang, W. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure, 27:125-133.e4, 2019 Cited by PubMed: 30503777 DOI: 10.1016/j.str.2018.10.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.246 Å)

Structure validation