6CMJ
Human CAMKK2 with GSK650393
Summary for 6CMJ
Entry DOI | 10.2210/pdb6cmj/pdb |
Descriptor | Calcium/calmodulin-dependent protein kinase kinase 2, 2-(2-methylpropyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | kinase, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q96RR4 |
Total number of polymer chains | 2 |
Total formula weight | 74628.44 |
Authors | Williams, S.P.,Reid, R.A.,Price, D.J.,Drewry, D.H. (deposition date: 2018-03-05, release date: 2018-04-04, Last modification date: 2018-05-16) |
Primary citation | Price, D.J.,Drewry, D.H.,Schaller, L.T.,Thompson, B.D.,Reid, P.R.,Maloney, P.R.,Liang, X.,Banker, P.,Buckholz, R.G.,Selley, P.K.,McDonald, O.B.,Smith, J.L.,Shearer, T.W.,Cox, R.F.,Williams, S.P.,Reid, R.A.,Tacconi, S.,Faggioni, F.,Piubelli, C.,Sartori, I.,Tessari, M.,Wang, T.Y. An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg. Med. Chem. Lett., 28:1958-1963, 2018 Cited by PubMed: 29653895DOI: 10.1016/j.bmcl.2018.03.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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