6CMJ

Human CAMKK2 with GSK650393

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Calcium/calmodulin-dependent protein kinase kinase 2	polymer	321	36712.6	2	UniProt (Q96RR4) Pfam (PF00069)	Homo sapiens (Human)	CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaMKK beta
2	C, H (A, B)	2-(2-methylpropyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	non-polymer		370.4	2	Chemie (F6J)
3	D, E, F, I, J... (A, B)	FORMIC ACID	non-polymer		46.0	6	Chemie (FMT)
4	G, L, M (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	N, O (A, B)	water	water		18.0	229	Chemie (HOH)

Sequence modifications

A, B: 149 - 465 (UniProt: Q96RR4)

PDB	External Database	Details
Met 130	-	expression tag
Asn 131	-	expression tag
Ala 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
Gly 139	-	expression tag
Ser 140	-	expression tag
Ala 141	-	expression tag
Glu 142	-	expression tag
Asn 143	-	expression tag
Leu 144	-	expression tag
Tyr 145	-	expression tag
Phe 146	-	expression tag
Gln 147	-	expression tag
Gly 148	-	expression tag
Asp 163	Asn 163	conflict
-	Gly 206	deletion
-	Phe 207	deletion
-	Pro 208	deletion
-	Arg 209	deletion
-	Arg 210	deletion
-	Pro 211	deletion
-	Pro 212	deletion
-	Pro 213	deletion
-	Arg 214	deletion
-	Gly 215	deletion
-	Thr 216	deletion
-	Arg 217	deletion
-	Pro 218	deletion
-	Ala 219	deletion
-	Pro 220	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73425.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1203.2
All*	Total formula weight	74628.4

*Water molecules are not included.