6CF7
Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796
Summary for 6CF7
Entry DOI | 10.2210/pdb6cf7/pdb |
Descriptor | Hemagglutinin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | glycoprotein, ectodomain, n-glycosylation, viral protein |
Biological source | Influenza A virus (A/Solomon Islands/3/2006(H1N1)) More |
Total number of polymer chains | 2 |
Total formula weight | 59322.77 |
Authors | Kadam, R.U.,Wilson, I.A. (deposition date: 2018-02-13, release date: 2019-02-13, Last modification date: 2023-10-04) |
Primary citation | van Dongen, M.J.P.,Kadam, R.U.,Juraszek, J.,Lawson, E.,Brandenburg, B.,Schmitz, F.,Schepens, W.B.G.,Stoops, B.,van Diepen, H.A.,Jongeneelen, M.,Tang, C.,Vermond, J.,van Eijgen-Obregoso Real, A.,Blokland, S.,Garg, D.,Yu, W.,Goutier, W.,Lanckacker, E.,Klap, J.M.,Peeters, D.C.G.,Wu, J.,Buyck, C.,Jonckers, T.H.M.,Roymans, D.,Roevens, P.,Vogels, R.,Koudstaal, W.,Friesen, R.H.E.,Raboisson, P.,Dhanak, D.,Goudsmit, J.,Wilson, I.A. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science, 363:-, 2019 Cited by PubMed: 30846569DOI: 10.1126/science.aar6221 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.719 Å) |
Structure validation
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