6CDY

Crystal structure of TEAD complexed with its inhibitor

Summary for 6CDY

• Entry DOI: 10.2210/pdb6cdy/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide (3 entities in total)
• Functional Keywords: transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 55715.18

Authors

LIU, S.,HAN, X.,LUO, X. (deposition date: 2018-02-09, release date: 2020-07-01, Last modification date: 2023-10-04)

• Primary citation: Li, Q.,Sun, Y.,Jarugumilli, G.K.,Liu, S.,Dang, K.,Cotton, J.L.,Xiol, J.,Chan, P.Y.,DeRan, M.,Ma, L.,Li, R.,Zhu, L.J.,Li, J.H.,Leiter, A.B.,Ip, Y.T.,Camargo, F.D.,Luo, X.,Johnson, R.L.,Wu, X.,Mao, J.; Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.; Cell Stem Cell, 26:675-692.e8, 2020; PubMed: 32259481; DOI: 10.1016/j.stem.2020.03.002

Experimental method

X-RAY DIFFRACTION (2.32 Å)