6CDY
Crystal structure of TEAD complexed with its inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transcriptional enhancer factor TEF-4 | polymer | 240 | 27489.1 | 2 | UniProt (Q15562) Pfam (PF17725) In PDB | Homo sapiens (Human) | TEA domain family member 2,TEAD-2 |
2 | A, B | 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide | non-polymer | 368.5 | 2 | Chemie (EY1) | |||
3 | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, B: 217 - 447 (UniProt: Q15562)
PDB | External Database | Details |
---|---|---|
Met 216 | - | initiating methionine |
Val 448 | - | expression tag |
Glu 449 | - | expression tag |
His 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
His 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 54978.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 737.0 | |
All* | Total formula weight | 55715.2 |