6C8S

Loganic acid methyltransferase with SAH

Summary for 6C8S

Entry DOI	10.2210/pdb6c8s/pdb
Descriptor	Loganic acid O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
Functional Keywords	loganic acid, methyltransferase, plant protein, transferase
Biological source	Catharanthus roseus (Madagascar periwinkle)
Total number of polymer chains	2
Total formula weight	87048.88
Authors	Petronikolou, N.,Nair, S.K. (deposition date: 2018-01-25, release date: 2018-02-21, Last modification date: 2023-10-04)
Primary citation	Petronikolou, N.,Hollatz, A.J.,Schuler, M.A.,Nair, S.K. Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside. Chembiochem, 19:784-788, 2018 Cited by PubMed Abstract: Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. Loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin and demonstrates stereospecificity for the (6S,7R) substrate. We have biochemically characterized this biocatalyst and elucidated the basis for its strict substrate specificity. These studies could help facilitate the design of new classes of monoterpenoid indole alkaloids of pharmaceutical interest. PubMed: 29399933 DOI: 10.1002/cbic.201700679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation