6BHV
Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)
Summary for 6BHV
| Entry DOI | 10.2210/pdb6bhv/pdb |
| Descriptor | Poly [ADP-ribose] polymerase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) (3 entities in total) |
| Functional Keywords | parp-1, artd1, poly(adp-ribose) polymerase, non-hydrolyzable nad+ analog, parp, adp-ribose, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 122662.85 |
| Authors | Pascal, J.M.,Langelier, M.F. (deposition date: 2017-10-31, release date: 2018-02-28, Last modification date: 2023-10-04) |
| Primary citation | Langelier, M.F.,Zandarashvili, L.,Aguiar, P.M.,Black, B.E.,Pascal, J.M. NAD+analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains. Nat Commun, 9:844-844, 2018 Cited by PubMed: 29487285DOI: 10.1038/s41467-018-03234-8 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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