6BHV
Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue DQV A 1101 |
| Chain | Residue |
| A | HIS862 |
| A | ALA880 |
| A | TYR889 |
| A | MET890 |
| A | TYR896 |
| A | PHE897 |
| A | SER904 |
| A | TYR907 |
| A | GLU988 |
| A | HOH1202 |
| A | HOH1203 |
| A | GLY863 |
| A | HOH1212 |
| A | HOH1216 |
| A | SER864 |
| A | ASN868 |
| A | GLY871 |
| A | ILE872 |
| A | GLY876 |
| A | LEU877 |
| A | ARG878 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue DQV B 1101 |
| Chain | Residue |
| B | HIS862 |
| B | GLY863 |
| B | SER864 |
| B | ASN868 |
| B | GLY871 |
| B | ILE872 |
| B | GLN875 |
| B | GLY876 |
| B | LEU877 |
| B | ARG878 |
| B | GLY888 |
| B | TYR889 |
| B | MET890 |
| B | GLY894 |
| B | TYR896 |
| B | PHE897 |
| B | SER904 |
| B | TYR907 |
| B | GLU988 |
| B | HOH1208 |
| B | HOH1216 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue DQV C 1101 |
| Chain | Residue |
| C | HIS862 |
| C | GLY863 |
| C | SER864 |
| C | ASN868 |
| C | GLY871 |
| C | ILE872 |
| C | GLY876 |
| C | LEU877 |
| C | ARG878 |
| C | TYR889 |
| C | MET890 |
| C | TYR896 |
| C | PHE897 |
| C | SER904 |
| C | TYR907 |
| C | GLU988 |
| C | HOH1210 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue DQV D 1101 |
| Chain | Residue |
| D | HIS862 |
| D | GLY863 |
| D | SER864 |
| D | ASN868 |
| D | GLY871 |
| D | ILE872 |
| D | GLY876 |
| D | LEU877 |
| D | ARG878 |
| D | ALA880 |
| D | TYR889 |
| D | MET890 |
| D | TYR896 |
| D | PHE897 |
| D | SER904 |
| D | TYR907 |
| D | GLU988 |
| D | HOH1203 |
| D | HOH1205 |
| D | HOH1217 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7852410","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9315851","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UGN5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
