6B2E
Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4.
Summary for 6B2E
Entry DOI | 10.2210/pdb6b2e/pdb |
Related | 6BIU |
Related PRD ID | PRD_900012 |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total) |
Functional Keywords | phosphorylated, active, heterotrimer, kinase., transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 135352.02 |
Authors | Ngoei, K.R.W.,Langendorf, C.G.,Ling, N.X.Y.,Hoque, A.,Johnson, S.,Camerino, M.C.,Walker, S.R.,Bozikis, Y.E.,Dite, T.A.,Ovens, A.J.,Smiles, W.J.,Jacobs, R.,Huang, H.,Parker, M.W.,Scott, J.W.,Rider, M.H.,Kemp, B.E.,Foitzik, R.C.,Baell, J.B.,Oakhill, J.S. (deposition date: 2017-09-19, release date: 2018-04-25, Last modification date: 2023-10-04) |
Primary citation | Ngoei, K.R.W.,Langendorf, C.G.,Ling, N.X.Y.,Hoque, A.,Varghese, S.,Camerino, M.A.,Walker, S.R.,Bozikis, Y.E.,Dite, T.A.,Ovens, A.J.,Smiles, W.J.,Jacobs, R.,Huang, H.,Parker, M.W.,Scott, J.W.,Rider, M.H.,Foitzik, R.C.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25:728-737.e9, 2018 Cited by PubMed: 29657085DOI: 10.1016/j.chembiol.2018.03.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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