6AKR
Crystal structure of the PDE4D catalytic domain in complex with osthole
Summary for 6AKR
Entry DOI | 10.2210/pdb6akr/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, ... (4 entities in total) |
Functional Keywords | phosphodiesterase 4d, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 168733.38 |
Authors | |
Primary citation | Wang, S.,Xie, Y.,Huo, Y.W.,Li, Y.,Abel, P.W.,Jiang, H.,Zou, X.,Jiao, H.Z.,Kuang, X.,Wolff, D.W.,Huang, Y.G.,Casale, T.B.,Panettieri Jr., R.A.,Wei, T.,Cao, Z.,Tu, Y. Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma. Sci.Signal., 13:-, 2020 Cited by PubMed: 33234690DOI: 10.1126/scisignal.aax0273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.326 Å) |
Structure validation
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