6AKR
Crystal structure of the PDE4D catalytic domain in complex with osthole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 364 | 41808.2 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | E, F, H, I, K... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, J, M, P (A, B, C, D) | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one | non-polymer | 244.3 | 4 | Chemie (A0O) | |||
| 4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 317 - 676 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Gly 313 | - | expression tag |
| Ser 314 | - | expression tag |
| His 315 | - | expression tag |
| Met 316 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167233.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1500.4 | |
| All* | Total formula weight | 168733.4 |
