6ADQ
Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis
Summary for 6ADQ
| Entry DOI | 10.2210/pdb6adq/pdb |
| EMDB information | 9610 |
| Descriptor | Cytochrome c oxidase subunit 2, Ubiquinol-cytochrome c reductase cytochrome b subunit, Cytochrome bc1 complex cytochrome c subunit, ... (23 entities in total) |
| Functional Keywords | respiratory, supercomplex, sod, mycobacterium, etc, lipoprotein, electron transport |
| Biological source | Mycobacterium smegmatis MC2 51 More |
| Total number of polymer chains | 24 |
| Total formula weight | 769566.28 |
| Authors | Gong, H.R.,Xu, A.,Gao, R.G.,Ji, W.X.,Wang, S.H.,Wang, Q.,Li, J.,Rao, Z.H. (deposition date: 2018-08-01, release date: 2018-11-14, Last modification date: 2025-09-17) |
| Primary citation | Gong, H.,Li, J.,Xu, A.,Tang, Y.,Ji, W.,Gao, R.,Wang, S.,Yu, L.,Tian, C.,Li, J.,Yen, H.Y.,Man Lam, S.,Shui, G.,Yang, X.,Sun, Y.,Li, X.,Jia, M.,Yang, C.,Jiang, B.,Lou, Z.,Robinson, C.V.,Wong, L.L.,Guddat, L.W.,Sun, F.,Wang, Q.,Rao, Z. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science, 362:-, 2018 Cited by PubMed Abstract: We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis. PubMed: 30361386DOI: 10.1126/science.aat8923 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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