5ZXB

Crystal structure of ACK1 with compound 10d

5ZXB の概要

• エントリーDOI: 10.2210/pdb5zxb/pdb
• 分子名称: Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide (3 entities in total)
• 機能のキーワード: inhibitor, kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64165.94

構造登録者

Hong, E.M.,Kim, H.L.,Sim, T.B. (登録日: 2018-05-18, 公開日: 2018-09-26, 最終更新日: 2024-03-27)

• 主引用文献: Cho, H.,Shin, I.,Ju, E.,Choi, S.,Hur, W.,Kim, H.,Hong, E.,Kim, N.D.,Choi, H.G.,Gray, N.S.,Sim, T.; First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.; J. Med. Chem., 61:8353-8373, 2018; PubMed: 30153003; DOI: 10.1021/acs.jmedchem.8b00882

実験手法

X-RAY DIFFRACTION (2.198 Å)