5ZWJ

Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045

Summary for 5ZWJ

Entry DOI	10.2210/pdb5zwj/pdb
Descriptor	Epidermal growth factor receptor, (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide (3 entities in total)
Functional Keywords	egfr t790m, c797s, eai045, signaling protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41224.58
Authors	Zhao, P.,Yun, C.H. (deposition date: 2018-05-15, release date: 2018-07-25, Last modification date: 2024-03-27)
Primary citation	Zhao, P.,Yao, M.Y.,Zhu, S.J.,Chen, J.Y.,Yun, C.H. Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem. Biophys. Res. Commun., 502:332-337, 2018 Cited by PubMed: 29802850 DOI: 10.1016/j.bbrc.2018.05.154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation