5ZUV

Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1

Summary for 5ZUV

Entry DOI	10.2210/pdb5zuv/pdb
Descriptor	Spike glycoprotein,Spike glycoprotein,inhibitor EK1, CHLORIDE ION (3 entities in total)
Functional Keywords	human coronavirus 229e, spike protein, s2 domain, hr1 motif, pan-coronavirus, viral protein, inhibitor
Biological source	Human coronavirus 229E (HCoV-229E) More
Total number of polymer chains	3
Total formula weight	44141.94
Authors	Yan, L.,Yang, B.,Wilson, I.A. (deposition date: 2018-05-08, release date: 2019-04-10, Last modification date: 2023-11-22)
Primary citation	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L. A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv, 5:eaav4580-eaav4580, 2019 Cited by PubMed: 30989115 DOI: 10.1126/sciadv.aav4580 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation