5ZUV

Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1

5ZUV の概要

• エントリーDOI: 10.2210/pdb5zuv/pdb
• 分子名称: Spike glycoprotein,Spike glycoprotein,inhibitor EK1, CHLORIDE ION (3 entities in total)
• 機能のキーワード: human coronavirus 229e, spike protein, s2 domain, hr1 motif, pan-coronavirus, viral protein, inhibitor
• 由来する生物種: Human coronavirus 229E (HCoV-229E); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44141.94

構造登録者

Yan, L.,Yang, B.,Wilson, I.A. (登録日: 2018-05-08, 公開日: 2019-04-10, 最終更新日: 2023-11-22)

• 主引用文献: Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.; A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.; Sci Adv, 5:eaav4580-eaav4580, 2019; PubMed: 30989115; DOI: 10.1126/sciadv.aav4580

実験手法

X-RAY DIFFRACTION (2.21 Å)