5ZTN

The crystal structure of human DYRK2 in complex with Curcumin

5ZTN の概要

• エントリーDOI: 10.2210/pdb5ztn/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (3 entities in total)
• 機能のキーワード: inhibitor of kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99778.61

構造登録者

Ji, C.G.,Xiao, J.Y. (登録日: 2018-05-04, 公開日: 2018-07-18, 最終更新日: 2023-11-22)

• 主引用文献: Banerjee, S.,Ji, C.,Mayfield, J.E.,Goel, A.,Xiao, J.,Dixon, J.E.,Guo, X.; Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.; Proc. Natl. Acad. Sci. U.S.A., 115:8155-8160, 2018; PubMed: 29987021; DOI: 10.1073/pnas.1806797115

実験手法

X-RAY DIFFRACTION (2.496 Å)