5ZQP

Tankyrase-2 in complex with compound 12

5ZQP の概要

• エントリーDOI: 10.2210/pdb5zqp/pdb
• 分子名称: Tankyrase-2, ZINC ION, 1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)-2H-spiro[1-benzofuran-3,4'-piperidin]-2-one, ... (7 entities in total)
• 機能のキーワード: tankyrase, parp, adp-ribosylation, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25210.63

構造登録者

Niwa, H.,Shirai, F.,Sato, S.,Yoshimoto, N.,Tsumura, T.,Okue, M.,Shirouzu, M.,Seimiya, H.,Umehara, T. (登録日: 2018-04-19, 公開日: 2019-04-03, 最終更新日: 2023-11-22)

• 主引用文献: Shirai, F.,Tsumura, T.,Yashiroda, Y.,Yuki, H.,Niwa, H.,Sato, S.,Chikada, T.,Koda, Y.,Washizuka, K.,Yoshimoto, N.,Abe, M.,Onuki, T.,Mazaki, Y.,Hirama, C.,Fukami, T.,Watanabe, H.,Honma, T.,Umehara, T.,Shirouzu, M.,Okue, M.,Kano, Y.,Watanabe, T.,Kitamura, K.,Shitara, E.,Muramatsu, Y.,Yoshida, H.,Mizutani, A.,Seimiya, H.,Yoshida, M.,Koyama, H.; Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.; J. Med. Chem., 62:3407-3427, 2019; PubMed: 30883102; DOI: 10.1021/acs.jmedchem.8b01888

実験手法

X-RAY DIFFRACTION (1.99 Å)