5ZKC

Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS

Summary for 5ZKC

Entry DOI	10.2210/pdb5zkc/pdb
Related	5ZK3 5ZK8 5ZKB
Descriptor	Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine (3 entities in total)
Functional Keywords	gpcr crystallography, rationally thermostabilized mutant, membrane protein-inhibitor complex, membrane protein/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	47611.59
Authors	Suno, R.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Iwata, S.,Kobayashi, T. (deposition date: 2018-03-23, release date: 2018-11-21, Last modification date: 2022-03-23)
Primary citation	Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T. Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor Nat. Chem. Biol., 14:1150-1158, 2018 Cited by PubMed: 30420692 DOI: 10.1038/s41589-018-0152-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation