5ZI0

Ketoreductase LbCR mutant - M8

Summary for 5ZI0

Descriptor3-oxoacyl-acyl carrier protein reductase (2 entities in total)
Functional Keywordsketoreductase, short-chain dehydrogenase/reductase (sdr), oxidoreductase
Biological sourceLactobacillus brevis (strain ATCC 367 / JCM 1170)
Total number of polymer chains4
Total molecular weight118269.93
Authors
Gong, X.M.,Zheng, G.W.,Xu, J.H. (deposition date: 2018-03-14, release date: 2019-01-16)
Primary citation
Gong, X.M.,Zhen, Q.,Li, F.L.,Zeng, B.B.,Zheng, G.W.,Xu, J.H.
Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor
Acs Catalysis, 9:147-153, 2019
DOI: 10.1021/acscatal.8b03382
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.302 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2194 0.2% 2.0% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5zi0
no rotation
Molmil generated image of 5zi0
rotated about x axis by 90°
Molmil generated image of 5zi0
rotated about y axis by 90°
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