Crystal structure of SmgGDS-558 and farnesylated RhoA complex

Summary for 5ZHX

DescriptorRap1 GTPase-GDP dissociation stimulator 1, Transforming protein RhoA, FARNESYL (3 entities in total)
Functional Keywordsarmadillo gef chaperone, oncoprotein
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight303175.37
Shimizu, H.,Toma-Fukai, S.,Shimizu, T. (deposition date: 2018-03-13, release date: 2018-09-05, Last modification date: 2018-10-03)
Primary citation
Shimizu, H.,Toma-Fukai, S.,Kontani, K.,Katada, T.,Shimizu, T.
GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.
Proc. Natl. Acad. Sci. U.S.A., 115:9563-9568, 2018
PubMed: 30190425 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1804740115
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.30190.3%12.5%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report