5ZHP

M3 muscarinic acetylcholine receptor in complex with a selective antagonist

5ZHP の概要

• エントリーDOI: 10.2210/pdb5zhp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, TETRAETHYLENE GLYCOL, ... (6 entities in total)
• 機能のキーワード: g protein coupled receptor, membrane protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97646.19

構造登録者

Liu, H.,Hofmann, J.,Fish, I.,Schaake, B.,Eitel, K.,Bartuschat, A.,Kaindl, J.,Rampp, H.,Banerjee, A.,Hubner, H.,Clark, M.J.,Vincent, S.G.,Fisher, J.,Heinrich, M.,Hirata, K.,Liu, X.,Sunahara, R.K.,Shoichet, B.K.,Kobilka, B.K.,Gmeiner, P. (登録日: 2018-03-13, 公開日: 2018-11-28, 最終更新日: 2023-11-22)

• 主引用文献: Liu, H.,Hofmann, J.,Fish, I.,Schaake, B.,Eitel, K.,Bartuschat, A.,Kaindl, J.,Rampp, H.,Banerjee, A.,Hubner, H.,Clark, M.J.,Vincent, S.G.,Fisher, J.T.,Heinrich, M.R.,Hirata, K.,Liu, X.,Sunahara, R.K.,Shoichet, B.K.,Kobilka, B.K.,Gmeiner, P.; Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists; Proc. Natl. Acad. Sci. U.S.A., 115:12046-12050, 2018; PubMed: 30404914; DOI: 10.1073/pnas.1813988115

実験手法

X-RAY DIFFRACTION (3.1 Å)