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5ZH2

CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-5

Summary for 5ZH2
Entry DOI10.2210/pdb5zh2/pdb
DescriptorLysine-tRNA ligase, LYSINE, (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ... (5 entities in total)
Functional Keywordskrs, ligase-ligase inhibitor complex, ligase
Biological sourcePlasmodium falciparum NF54 (Plasmodium falciparum (isolate NF54))
Total number of polymer chains2
Total formula weight118643.99
Authors
Babbar, P.,Malhotra, N.,Sharma, M.,Harlos, K.,Reddy, D.S.,Manickam, Y.,Sharma, A. (deposition date: 2018-03-11, release date: 2018-06-27, Last modification date: 2023-11-22)
Primary citationDas, P.,Babbar, P.,Malhotra, N.,Sharma, M.,Jachak, G.R.,Gonnade, R.G.,Shanmugam, D.,Harlos, K.,Yogavel, M.,Sharma, A.,Reddy, D.S.
Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61:5664-5678, 2018
Cited by
PubMed: 29779382
DOI: 10.1021/acs.jmedchem.8b00565
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.66 Å)
Structure validation

217705

건을2024-03-27부터공개중

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