5ZH2
CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLY284 |
| A | GLY552 |
| A | ALA285 |
| A | GLU308 |
| A | ARG330 |
| A | GLU346 |
| A | TYR348 |
| A | ASN503 |
| A | TYR505 |
| A | GLU507 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 9CU A 602 |
| Chain | Residue |
| A | ARG330 |
| A | GLU332 |
| A | HIS338 |
| A | ASN339 |
| A | PHE342 |
| A | GLU500 |
| A | VAL501 |
| A | LEU502 |
| A | LEU555 |
| A | ARG559 |
| A | ILE570 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 603 |
| Chain | Residue |
| A | TRP349 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 604 |
| Chain | Residue |
| A | HIS338 |
| A | LYS499 |
| A | ARG559 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MPO A 605 |
| Chain | Residue |
| A | GLN147 |
| B | ARG81 |
| B | LYS409 |
| B | ASN412 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | GLY284 |
| B | ALA285 |
| B | GLU308 |
| B | ARG330 |
| B | GLU346 |
| B | TYR348 |
| B | ASN503 |
| B | TYR505 |
| B | GLU507 |
| B | GLY552 |
| B | GLY554 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue 9CU B 602 |
| Chain | Residue |
| B | ARG330 |
| B | GLU332 |
| B | HIS338 |
| B | ASN339 |
| B | PHE342 |
| B | GLU500 |
| B | VAL501 |
| B | LEU502 |
| B | GLY554 |
| B | GLY556 |
| B | ARG559 |
| B | ILE570 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 604 |
| Chain | Residue |
| A | ARG108 |
