5ZGE
Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin
Replaces: 3Q6XSummary for 5ZGE
Entry DOI | 10.2210/pdb5zge/pdb |
Descriptor | Metallo-beta-lactamase type 2, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... (5 entities in total) |
Functional Keywords | ndm-1, metallo-beta-lactamase, antibiotic resistent, conformational change, antibiotic, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 52294.13 |
Authors | |
Primary citation | Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 30150473DOI: 10.1128/AAC.01579-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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