5ZEN
Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate
Summary for 5ZEN
Entry DOI | 10.2210/pdb5zen/pdb |
Descriptor | DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (5 entities in total) |
Functional Keywords | type ii topoisomerase, cleavage complex, dna-gate, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 97206.66 |
Authors | Chen, S.F.,Wang, Y.R.,Chan, N.L. (deposition date: 2018-02-27, release date: 2018-08-08, Last modification date: 2023-11-22) |
Primary citation | Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L. Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9:3085-3085, 2018 Cited by PubMed: 30082834DOI: 10.1038/s41467-018-05406-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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