Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate

Summary for 5ZEN

DescriptorDNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (5 entities in total)
Functional Keywordstype ii topoisomerase, cleavage complex, dna-gate, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight97206.66
Chen, S.F.,Wang, Y.R.,Chan, N.L. (deposition date: 2018-02-27, release date: 2018-08-08, Last modification date: 2018-08-15)
Primary citation
Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L.
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9:3085-3085, 2018
PubMed: 30082834 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-05406-y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.264800.2%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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