5ZBH

The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885

5ZBH の概要

• エントリーDOI: 10.2210/pdb5zbh/pdb
• 分子名称: Neuropeptide Y receptor type 1,T4 Lysozyme,Neuropeptide Y receptor type 1, dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (2 entities in total)
• 機能のキーワード: g protein-coupled receptor neuropeptide y y1 receptor inhibitor complex structure, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P25929
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61255.73

構造登録者

Yang, Z.,Han, S.,Zhao, Q.,Wu, B. (登録日: 2018-02-11, 公開日: 2018-04-25, 最終更新日: 2018-05-09)

• 主引用文献: Yang, Z.,Han, S.,Keller, M.,Kaiser, A.,Bender, B.J.,Bosse, M.,Burkert, K.,Kogler, L.M.,Wifling, D.,Bernhardt, G.,Plank, N.,Littmann, T.,Schmidt, P.,Yi, C.,Li, B.,Ye, S.,Zhang, R.,Xu, B.,Larhammar, D.,Stevens, R.C.,Huster, D.,Meiler, J.,Zhao, Q.,Beck-Sickinger, A.G.,Buschauer, A.,Wu, B.; Structural basis of ligand binding modes at the neuropeptide Y Y1receptor; Nature, 556:520-524, 2018; PubMed: 29670288; DOI: 10.1038/s41586-018-0046-x

実験手法

X-RAY DIFFRACTION (3 Å)