5Z9R

NMNAT as a specific chaperone antagonizing pathological condensation of phosphorylated tau

5Z9R の概要

• エントリーDOI: 10.2210/pdb5z9r/pdb
• 分子名称: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (2 entities in total)
• 機能のキーワード: antagonizing pathological condensation of phosphorylated tau, chaperone, transferase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63145.95

構造登録者

Dou, S.,Ma, X.,Li, D.,Liu, C. (登録日: 2018-02-05, 公開日: 2019-02-06, 最終更新日: 2023-11-22)

• 主引用文献: Ma, X.,Zhu, Y.,Lu, J.,Xie, J.,Li, C.,Shin, W.S.,Qiang, J.,Liu, J.,Dou, S.,Xiao, Y.,Wang, C.,Jia, C.,Long, H.,Yang, J.,Fang, Y.,Jiang, L.,Zhang, Y.,Zhang, S.,Zhai, R.G.,Liu, C.,Li, D.; Nicotinamide mononucleotide adenylyltransferase uses its NAD+substrate-binding site to chaperone phosphorylated Tau.; Elife, 9:-, 2020; PubMed: 32250733; DOI: 10.7554/eLife.51859

実験手法

X-RAY DIFFRACTION (2 Å)