5Z9N

S.aureus GyrB ATPase domain in complex with 4,6-dichloro-2-(methylthio)pyrimidine

Summary for 5Z9N

Entry DOI	10.2210/pdb5z9n/pdb
Descriptor	DNA gyrase subunit B, 4,6-dichloro-2-(methylsulfanyl)pyrimidine, SULFATE ION, ... (4 entities in total)
Functional Keywords	dna topoisomerase, antibacterial, drug target, fragment-base lead discovery, isomerase
Biological source	Escherichia coli K-12
Total number of polymer chains	1
Total formula weight	23284.80
Authors	Huang, X.,Zhou, H. (deposition date: 2018-02-03, release date: 2018-12-12, Last modification date: 2023-11-22)
Primary citation	Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm, 9:1619-1629, 2018 Cited by PubMed: 30429968 DOI: 10.1039/c8md00148k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation